Psoriasis is a persistent inflammatory and immune-mediated skin disease in which skin cells build up 10 times faster than normal and form plaques, silvery patches and dry skin and it affects 2-3% of the total population throughout the world. Many hereditary or environmental factors triggered the activation of several pro-inflammatory cytokines; such as tumor necrosis factor (TNF)-a, interferon (IFN) and interleukin (IL). It is associated with many simultaneous co-morbidities including cardiovascular diseases (arteriosclerosis, myocardial infarction and hypertension), metabolic diseases (obesity, insulin resistance and dyslipidemia), joint disorders (psoriatic arthritis, osteoporosis) and psychological problems (anxiety and depression). These comorbidities make the disease the main health concern that needs the assistance of dermatologists and other health care specialists. The topical agents and phototherapy used for psoriasis patients. Even though these methods are beneficial only for symptomatic efficient relief of skin lesions but not have an effect on primary causes of disease. This review summarizes the clinical manifestations, diagnosis, pathophysiological links and relationship that associate with psoriasis and common comorbidities and highlights the treatment strategies to control systemic inflammation and could diminish the concerns of related disorders in the future.
Loading....